Karen Smith, vice president of Friends of Broward County Library, distributes at-home coronavirus test kits in Fort Lauderdale, Fla., on Dec. 30. (Amy Beth Bennett/South Florida Sun-Sentinel/AP)

The United States is heading into the third year of the coronavirus pandemic with the extremely contagious omicron variant poised to ignite a firestorm of infection across the Southeast after exploding through the Northeast and Mid-Atlantic regions.

Lower vaccination rates and fewer mask and vaccine mandates have created a much different environment for the omicron variant to spread in the South, leaving experts unsure whether outbreaks will end up deadlier than in the North.